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Contraindicated (one)pentobarbital will reduce the extent or impact of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the extent or influence of etonogestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital increases toxicity of buprenorphine, exte